When selecting the best antigen for lateral flow cancer screening, it’s essential to consider markers that are both highly specific to cancer cells and expressed in the early stages of cancer.
We only select, those antigens that are easily detectable and present in a sufficient concentration in body fluids like blood, urine, endocervical swab or saliva.
Here are some of the best-known antigens currently used by us or investigated for lateral flow cancer screening:
How peanut agglutinin (PNA) detects the cancer-associated Thomsen–Friedenreich (TF) antigen, its research uses, its limits and the path to blood tests.
Why the Thomsen–Friedenreich (TF) antigen becomes exposed: cancer glycosylation changes, bacterial neuraminidase, inflammation, development and lab factors.
What causes high alpha-fetoprotein (AFP)? Liver cancer and liver disease, germ cell tumors, pregnancy, rare inherited causes, lab factors and what levels mean.
Carbohydrate antigen 72-4 (CA72-4) is a tumor-associated glycoprotein frequently studied as a biomarker for cancer, particularly gastric and gynecological malignancies. Here’s a detailed overview based on current research: Overview and…
Thomsen–Friedenreich (TF) Antigen: A Key Marker in Cancer Biology The Thomsen–Friedenreich (TF) antigen, also known as CD176, is a simple two‑sugar structure (galactose + N‑acetylgalactosamine) normally hidden on healthy cells….
KRAS mutations are among the most common oncogenic drivers in human cancers, notably in pancreatic, colorectal, and lung cancers. The KRAS gene encodes a protein that functions as a molecular…
TP53 (Tumor Protein p53)
Alpha-Fetoprotein (AFP) is a well-established cancer biomarker with diverse clinical applications, especially in liver and germ cell tumors. Here’s a detailed summary of its biological role, diagnostic value, prognostic utility,…
Prostate-Specific Antigen (PSA) is a widely used cancer biomarker, particularly for prostate cancer (PCa). While it has transformed prostate cancer screening and monitoring, it also has notable limitations. Here’s a…
CEA is a cell adhesion molecule normally produced during fetal development. In adults, it is usually undetectable in the blood, but it may be re-expressed and elevated in certain cancers,…